Expression of Carbonic Anhydrase IX (CA9)

Stable Identifier
R-HSA-1235035
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
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Expression of Carbonic Anhydrase IX (CA9)
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The gene encoding carbonic anhydrase IX (CA9) is transcribed to yield mRNA and the mRNA is translated to yield protein. Hypoxia-inducible factor binds the promoter of CA9 and enhances expression of CA9.

Literature References
PubMed ID Title Journal Year
11156414 Hypoxia-inducible expression of tumor-associated carbonic anhydrases

Maxwell, PH, Harris, AL, Wykoff, CC, Turner, KJ, Pugh, CW, Watson, PH, Pastorek, J, Wilson, GD, Turley, H, Sibtain, A, Beasley, NJ, Ratcliffe, PJ, Talks, KL

Cancer Res 2000
15184875 Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma

A de Weijert, MC, Verhaegh, GW, Schalken, JA, Oosterwijk, E, Grabmaier, K

Oncogene 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
HIF:CBP:p300 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-03-20)
Reviewed
Rantanen, K  (2012-05-19)
Created
May, B  (2011-03-21)
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