Reactome | HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

Stable Identifier

R-HSA-1234171

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

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HIF-alpha (HIF1A, HIF2A (EPAS1, MOP2), HIF3A isoform 1) forms a heterodimer with ARNT (HIF1-beta) (Wang et al. 1995, Jiang et al. 1996, Hogenesch et al. 1997, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003, Heikkilä et al. 2011, Zhang et al. 2014, Kim et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
7539918	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Semenza, GL, Rue, EA, Wang, GL, Jiang, BH	Proc Natl Acad Sci U S A	1995
24613356	Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia Duan, C, Zhang, P, Li, Y, Yao, Q, Lu, L, Chen, PJ	Cell Rep	2014
14668441	Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor Gardner, KH, Erbel, PJ, Karakuzu, O, Card, PB, Bruick, RK	Proc Natl Acad Sci U S A	2003
26160453	The action of HIF-3α variants on HIF-2α-HIF-1β heterodimer formation is directly probed in live cells Kim, SH, Chung, HS, Park, H, Kim, SY, Yang, EG, Hwang, D	Exp Cell Res	2015
9000051	Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells Russell, DW, Tian, H, McKnight, SL	Genes Dev	1997
21479871	Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response Myllyharju, J, Heikkilä, M, Kivirikko, KI, Pasanen, A	Cell Mol Life Sci	2011
9079689	Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway Pray-Grant, M, Perdew, GH, Jackiw, VH, Hogenesch, JB, Brown, RC, Chan, WK, Gu, YZ, Bradfield, CA	J Biol Chem	1997
8663540	Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 Semenza, GL, Rue, E, Wang, GL, Jiang, BH, Roe, R	J Biol Chem	1996
9840812	Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha Moran, SM, Hogenesch, JB, Wartman, L, Gu, YZ, Bradfield, CA	Gene Expr	1998