Reactome | HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

Stable Identifier

R-HSA-1234171

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

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HIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) forms a heterodimer with ARNT (HIF1-beta) (Wang et al. 1995, Jiang et al. 1996, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
14668441	Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor Erbel, PJ, Card, PB, Karakuzu, O, Bruick, RK, Gardner, KH	Proc Natl Acad Sci U S A	2003
7539918	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Wang, GL, Jiang, BH, Rue, EA, Semenza, GL	Proc Natl Acad Sci U S A	1995
9000051	Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells Tian, H, McKnight, SL, Russell, DW	Genes Dev	1997
8663540	Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 Jiang, BH, Rue, E, Wang, GL, Roe, R, Semenza, GL	J Biol Chem	1996
9840812	Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha Gu, YZ, Moran, SM, Hogenesch, JB, Wartman, L, Bradfield, CA	Gene Expr	1998