HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

Stable Identifier
Reaction [binding]
Homo sapiens
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HIF-alpha (HIF1A, HIF2A (EPAS1, MOP2), HIF3A isoform 1) forms a heterodimer with ARNT (HIF1-beta) (Wang et al. 1995, Jiang et al. 1996, Hogenesch et al. 1997, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003, Heikkilä et al. 2011, Zhang et al. 2014, Kim et al. 2015).
Literature References
PubMed ID Title Journal Year
7539918 Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Semenza, GL, Rue, EA, Wang, GL, Jiang, BH

Proc Natl Acad Sci U S A 1995
24613356 Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia

Duan, C, Zhang, P, Li, Y, Yao, Q, Lu, L, Chen, PJ

Cell Rep 2014
14668441 Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor

Gardner, KH, Erbel, PJ, Karakuzu, O, Card, PB, Bruick, RK

Proc Natl Acad Sci U S A 2003
26160453 The action of HIF-3α variants on HIF-2α-HIF-1β heterodimer formation is directly probed in live cells

Kim, SH, Chung, HS, Park, H, Kim, SY, Yang, EG, Hwang, D

Exp Cell Res 2015
9000051 Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Russell, DW, Tian, H, McKnight, SL

Genes Dev 1997
21479871 Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

Myllyharju, J, Heikkilä, M, Kivirikko, KI, Pasanen, A

Cell Mol Life Sci 2011
9079689 Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

Pray-Grant, M, Perdew, GH, Jackiw, VH, Hogenesch, JB, Brown, RC, Chan, WK, Gu, YZ, Bradfield, CA

J Biol Chem 1997
8663540 Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

Semenza, GL, Rue, E, Wang, GL, Jiang, BH, Roe, R

J Biol Chem 1996
9840812 Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha

Moran, SM, Hogenesch, JB, Wartman, L, Gu, YZ, Bradfield, CA

Gene Expr 1998
Orthologous Events
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