Reactome | Prosalpha2 [nucleoplasm]

Prosalpha2 [nucleoplasm]

Stable Identifier

R-DME-174345

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

PSMA2, P40301

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G1/S DNA Damage Checkpoints (Drosophila melanogaster)
    - p53-Independent G1/S DNA Damage Checkpoint (Drosophila melanogaster)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Cyclin E associated events during G1/S transition (Drosophila melanogaster)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
      - SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX2 (Drosophila melanogaster)
      - Regulation of RUNX2 expression and activity (Drosophila melanogaster)
        
        26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional regulation by RUNX3 (Drosophila melanogaster)
      - Regulation of RUNX3 expression and activity (Drosophila melanogaster)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha2 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P40301 Prosalpha2

Gene Names

Prosalpha2, PROS-25, Pros25, CG5266

Chain

chain:1-234

Reference Genes

BioGPS Gene:41531 Prosalpha2

CTD Gene:41531 Prosalpha2

KEGG:dme:Dmel_CG5266 Prosalpha2

Monarch:41531 Prosalpha2

NCBI Gene:41531 Prosalpha2

UCSC:P40301 Prosalpha2

Reference Transcript

RefSeq:NM_079604.3 Prosalpha2

Other Identifiers

153303_at

1635872_at

41531

GO:0000502

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0019773

GO:0030163

GO:0043161

GO:0051603

Participates

as a component of

20S CP outer ring [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

PROS25 [nucleoplasm]

PROS25 [cytosol]

Prosalpha2 [secretory granule lumen]

Prosalpha2 [extracellular region]

Prosalpha2 [ficolin-1-rich granule lumen]

Prosalpha2 [cytosol]

Inferred From

PSMA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_524328.1

ENSEMBL

FBtr0082590, FBgn0086134, FBpp0082062

FlyBase

FBgn0086134

PRO

P40301

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7JWV5 Q7JWV5			0.621	3
UniProt:Q9XZJ4 Prosalpha1	4	PROSalpha6 [nucleoplasm] (R-DME-216186) PROSalpha6 [cytosol] (R-DME-205787) Prosalpha1 [nucleoplasm] (R-DME-174314) Prosalpha1 [cytosol] (R-DME-68734)	0.621	3
UniProt:P12881 Prosalpha6	4	PROS35 [nucleoplasm] (R-DME-216129) PROS35 [cytosol] (R-DME-206188) Prosalpha6 [nucleoplasm] (R-DME-174333) Prosalpha6 [cytosol] (R-DME-68724)	0.547	2
UniProt:Q7K148	6	Prosbeta5 [cytosol] (R-DME-9908135) Prosbeta5 [cytosol] (R-DME-9908126) Prosbeta5 [cytosol] (R-DME-9908127) Prosbeta5 [cytosol] (R-DME-68762) Prosbeta5 [nucleoplasm] (R-DME-174344) Prosbeta5 [cytosol] (R-DME-68753)	0.547	2
UniProt:Q9XYN7 Prosbeta3	4	PROSbeta3 [nucleoplasm] (R-DME-216230) PROSbeta3 [cytosol] (R-DME-206158) Prosbeta3 [nucleoplasm] (R-DME-174341) Prosbeta3 [cytosol] (R-DME-68747)	0.547	2
UniProt:Q9VUJ1 Prosbeta2	10	PROSbeta2 [nucleoplasm] (R-DME-216237) PROSbeta2 [cytosol] (R-DME-206031) Prosbeta2 [secretory granule lumen] (R-DME-6803279) Prosbeta2 [extracellular region] (R-DME-6806449) Prosbeta2 [ficolin-1-rich granule lumen] (R-DME-6803312) Prosbeta2 [cytosol] (R-DME-9908145) Prosbeta2 [cytosol] (R-DME-9908123-2) Prosbeta2 [cytosol] (R-DME-68741-2) Prosbeta2 [nucleoplasm] (R-DME-174331) Prosbeta2 [cytosol] (R-DME-68759)	0.547	2
UniProt:Q9VK14 Q9VK14			0.547	2
UniProt:Q9VJJ0 CG17331	4	CG17331 [nucleoplasm] (R-DME-216116) CG17331 [cytosol] (R-DME-206285) Prosbeta4 [nucleoplasm] (R-DME-174335) Prosbeta4 [cytosol] (R-DME-68744)	0.547	4
UniProt:Q9W414	2	Rpt4 [nucleoplasm] (R-DME-174319) Rpt4 [cytosol] (R-DME-68783)	0.547	2
UniProt:P18053	2	Prosalpha3 [nucleoplasm] (R-DME-174324) Prosalpha3 [cytosol] (R-DME-68730)	0.547	4
UniProt:Q95083 Prosalpha5	7	PROSMA5 [nucleoplasm] (R-DME-216225) PROSMA5 [cytosol] (R-DME-205764) Prosalpha5 [secretory granule lumen] (R-DME-6803316) Prosalpha5 [extracellular region] (R-DME-6806459) Prosalpha5 [ficolin-1-rich granule lumen] (R-DME-6803328) Prosalpha5 [nucleoplasm] (R-DME-174340) Prosalpha5 [cytosol] (R-DME-68732)	0.547	2
UniProt:P48601 Rpt2	4	PROS26.4 [nucleoplasm] (R-DME-216113) PROS26.4 [cytosol] (R-DME-206110) PSMC1 [nucleoplasm] (R-DME-174338) PSMC1 [cytosol] (R-DME-68768)	0.547	2
UniProt:Q9VNA5 Prosbeta7	5	CG12000 [nucleoplasm] (R-DME-216212) CG12000 [cytosol] (R-DME-205917) Prosbeta7 [cytosol] (R-DME-9908138) Prosbeta7 [nucleoplasm] (R-DME-174343) Prosbeta7 [cytosol] (R-DME-68750)	0.547	3
UniProt:O18413 Rpt6	4	PROS45 [nucleoplasm] (R-DME-216274) PROS45 [cytosol] (R-DME-206026) PSMC5 [nucleoplasm] (R-DME-174312) PSMC5 [cytosol] (R-DME-68780)	0.547	3
UniProt:Q9V5C6 Prosalpha7	4	PROSalpha7 [nucleoplasm] (R-DME-216210) PROSalpha7 [cytosol] (R-DME-205958) Prosalpha7 [nucleoplasm] (R-DME-174323) Prosalpha7 [cytosol] (R-DME-68728)	0.547	2