Reactome | Rpt4 [nucleoplasm]

Rpt4 [nucleoplasm]

Stable Identifier

R-DME-174319

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

PSMC6, Q9W414

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G1/S DNA Damage Checkpoints (Drosophila melanogaster)
    - p53-Independent G1/S DNA Damage Checkpoint (Drosophila melanogaster)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Cyclin E associated events during G1/S transition (Drosophila melanogaster)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
      - SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)

DNA Replication (Drosophila melanogaster)

- DNA Replication Pre-Initiation (Drosophila melanogaster)
  - Assembly of the pre-replicative complex (Drosophila melanogaster)
    - Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)
      - 26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX2 (Drosophila melanogaster)
      - Regulation of RUNX2 expression and activity (Drosophila melanogaster)
        
        26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional regulation by RUNX3 (Drosophila melanogaster)
      - Regulation of RUNX3 expression and activity (Drosophila melanogaster)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Hedgehog (Drosophila melanogaster)
  - Hedgehog 'on' state (Drosophila melanogaster)
    - GLI2,3 are degraded by the proteasome (Drosophila melanogaster)
      - 26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)
        
        Rpt4 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W414

Gene Names

Rpt4

Reference Genes

BioGPS Gene:31567 Rpt4

CTD Gene:31567 Rpt4

ENSEMBL:FBgn0028685

FlyBase:FBgn0028685

KEGG:dme:Dmel_CG3455 Rpt4

Monarch:31567 Rpt4

NCBI Gene:31567 Rpt4

UCSC:Q9W414 Rpt4

Reference Transcript

RefSeq:NM_132080.4 Rpt4

Other Identifiers

144244_at

1640710_at

31567

GO:0000166

GO:0000502

GO:0001163

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006355

GO:0008540

GO:0016787

GO:0016853

GO:0016887

GO:0030163

GO:0030707

GO:0031597

GO:0036402

GO:0036503

GO:0043161

GO:0045899

GO:0048856

GO:1901800

GO:1901838

Participates

as a component of

PSMC3:PSMC6 [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

Rpt4 [cytosol]

Inferred From

PSMC6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_572308.3

FlyBase

FBgn0028685

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7KMQ0 Rpt1	7	RPT1 [nucleoplasm] (R-DME-216289) RPT1 [cytosol] (R-DME-205898) Rpt1 [secretory granule lumen] (R-DME-6800994) Rpt1 [extracellular region] (R-DME-6806472) Rpt1 [ficolin-1-rich granule lumen] (R-DME-6800421) Rpt1 [nucleoplasm] (R-DME-174332) Rpt1 [cytosol] (R-DME-68771)	0.547	2
UniProt:P40301 Prosalpha2	7	PROS25 [nucleoplasm] (R-DME-216177) PROS25 [cytosol] (R-DME-206278) Prosalpha2 [secretory granule lumen] (R-DME-6803329) Prosalpha2 [extracellular region] (R-DME-6806506) Prosalpha2 [ficolin-1-rich granule lumen] (R-DME-6803285) Prosalpha2 [nucleoplasm] (R-DME-174345) Prosalpha2 [cytosol] (R-DME-68726)	0.547	2
UniProt:Q9VFS8	1	PSMD9 [cytosol] (R-DME-68810)	0.547	2
UniProt:Q9VJJ0 CG17331	4	CG17331 [nucleoplasm] (R-DME-216116) CG17331 [cytosol] (R-DME-206285) Prosbeta4 [nucleoplasm] (R-DME-174335) Prosbeta4 [cytosol] (R-DME-68744)	0.547	2
UniProt:P48601 Rpt2	4	PROS26.4 [nucleoplasm] (R-DME-216113) PROS26.4 [cytosol] (R-DME-206110) PSMC1 [nucleoplasm] (R-DME-174338) PSMC1 [cytosol] (R-DME-68768)	0.547	3
UniProt:O18413 Rpt6	4	PROS45 [nucleoplasm] (R-DME-216274) PROS45 [cytosol] (R-DME-206026) PSMC5 [nucleoplasm] (R-DME-174312) PSMC5 [cytosol] (R-DME-68780)	0.547	2
UniProt:Q8STG9 Q8STG9			0.527	2
UniProt:P13607 ATNA			0.527	2

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