Reactome | Prosalpha1 [nucleoplasm]

Prosalpha1 [nucleoplasm]

Stable Identifier

R-DME-174314

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

PSMA6, Q9XZJ4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G1/S DNA Damage Checkpoints (Drosophila melanogaster)
    - p53-Independent G1/S DNA Damage Checkpoint (Drosophila melanogaster)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Cyclin E associated events during G1/S transition (Drosophila melanogaster)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
      - SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX2 (Drosophila melanogaster)
      - Regulation of RUNX2 expression and activity (Drosophila melanogaster)
        
        26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional regulation by RUNX3 (Drosophila melanogaster)
      - Regulation of RUNX3 expression and activity (Drosophila melanogaster)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha1 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9XZJ4 Prosalpha1

Gene Names

Prosalpha1, Prosalpha6, CG18495

Chain

chain:1-244

Reference Genes

BioGPS Gene:246582 Prosalpha1

BioGPS Gene:45780 Prosalpha1

CTD Gene:45780 Prosalpha1

KEGG:dme:Dmel_CG18495 Prosalpha1

KEGG:dme:Dmel_CG30382 Prosalpha1

Monarch:246582 Prosalpha1

Monarch:45780 Prosalpha1

NCBI Gene:246582 Prosalpha1

NCBI Gene:45780 Prosalpha1

UCSC:Q9XZJ4 Prosalpha1

Reference Transcript

Other Identifiers

141501_at

1633010_s_at

246582

45780

GO:0000502

GO:0003674

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0016787

GO:0019773

GO:0030163

GO:0043161

GO:0051603

Participates

as a component of

20S CP outer ring [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

PROSalpha6 [nucleoplasm]

PROSalpha6 [cytosol]

Prosalpha1 [cytosol]

Inferred From

PSMA6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_724614.1, NP_524837.2

ENSEMBL

FBpp0087968, FBpp0087969, FBtr0302223, FBgn0050382, FBpp0087970, FBtr0088896, FBtr0088895, FBpp0291433, FBtr0088894, FBgn0263121

FlyBase

FBgn0263121

PRO

Q9XZJ4

GlyGen

Q9XZJ4

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40301 Prosalpha2	7	PROS25 [nucleoplasm] (R-DME-216177) PROS25 [cytosol] (R-DME-206278) Prosalpha2 [secretory granule lumen] (R-DME-6803329) Prosalpha2 [extracellular region] (R-DME-6806506) Prosalpha2 [ficolin-1-rich granule lumen] (R-DME-6803285) Prosalpha2 [nucleoplasm] (R-DME-174345) Prosalpha2 [cytosol] (R-DME-68726)	0.621	3
UniProt:P22769 Prosalpha4	4	PROS28.1 [nucleoplasm] (R-DME-216125) PROS28.1 [cytosol] (R-DME-206179) Prosalpha4 [nucleoplasm] (R-DME-174351) Prosalpha4 [cytosol] (R-DME-68736)	0.621	3
UniProt:Q7K148	6	Prosbeta5 [cytosol] (R-DME-9908135) Prosbeta5 [cytosol] (R-DME-9908126) Prosbeta5 [cytosol] (R-DME-9908127) Prosbeta5 [cytosol] (R-DME-68762) Prosbeta5 [nucleoplasm] (R-DME-174344) Prosbeta5 [cytosol] (R-DME-68753)	0.527	2
UniProt:Q01070 ESMC			0.488	2
UniProt:Q9W1V2 Q9W1V2			0.488	2
UniProt:M9NFI9 M9NFI9			0.462	2

Cite Us!