Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PROS45 [nucleoplasm]
Stable Identifier
R-DME-216274
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
CLK is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [nucleoplasm] (Drosophila melanogaster)
PROS45 [nucleoplasm] (Drosophila melanogaster)
Degradation of CRY (Drosophila melanogaster)
Nuclear CRY is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [nucleoplasm] (Drosophila melanogaster)
PROS45 [nucleoplasm] (Drosophila melanogaster)
Degradation of PER (Drosophila melanogaster)
Nuclear PER is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [nucleoplasm] (Drosophila melanogaster)
PROS45 [nucleoplasm] (Drosophila melanogaster)
Degradation of TIM (Drosophila melanogaster)
Nuclear TIM is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [nucleoplasm] (Drosophila melanogaster)
PROS45 [nucleoplasm] (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
N-HH ligand bound to PTC receptor complex (Drosophila melanogaster)
Nuclear CI is degraded (Drosophila melanogaster)
Ubiquitinated CI is degraded by the proteasome complex (Drosophila melanogaster)
26S proteasome [nucleoplasm] (Drosophila melanogaster)
PROS45 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O18413 Rpt6
Gene Names
Rpt6, DUG, Pros45, Ug, CG1489
Chain
chain:1-405
Reference Genes
BioGPS Gene:33105 Rpt6
CTD Gene:33105 Rpt6
KEGG:dme:Dmel_CG1489 Rpt6
Monarch:33105 Rpt6
NCBI Gene:33105 Rpt6
UCSC:O18413 Rpt6
Reference Transcript
RefSeq:NM_134603.2 Rpt6
Other Identifiers
154351_at
1639784_at
33105
GO:0000166
GO:0000502
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0008540
GO:0016787
GO:0016887
GO:0030163
GO:0036402
GO:0043161
GO:1901800
Participates
as a component of
26S proteasome [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
PROS45 [cytosol]
PSMC5 [nucleoplasm]
PSMC5 [cytosol]
Cross References
RefSeq
NP_608447.1
ENSEMBL
FBgn0020369
,
FBtr0077189
,
FBpp0076890
FlyBase
FBgn0020369
PRO
O18413
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VSE9 Q9VSE9
0.621
3
UniProt:Q9VCE1
3
Atg6 [cytosol]
(R-DME-6782989)
phospho-Atg6 [cytosol]
(R-DME-5682391)
Atg6 [cytosol]
(R-DME-1632841)
0.621
3
UniProt:Q9W414
2
Rpt4 [nucleoplasm]
(R-DME-174319)
Rpt4 [cytosol]
(R-DME-68783)
0.547
2
UniProt:Q7KMQ0 Rpt1
7
RPT1 [nucleoplasm]
(R-DME-216289)
RPT1 [cytosol]
(R-DME-205898)
Rpt1 [secretory granule lumen]
(R-DME-6800994)
Rpt1 [extracellular region]
(R-DME-6806472)
Rpt1 [ficolin-1-rich granule lumen]
(R-DME-6800421)
Rpt1 [nucleoplasm]
(R-DME-174332)
Rpt1 [cytosol]
(R-DME-68771)
0.547
2
UniProt:P48601 Rpt2
4
PROS26.4 [nucleoplasm]
(R-DME-216113)
PROS26.4 [cytosol]
(R-DME-206110)
PSMC1 [nucleoplasm]
(R-DME-174338)
PSMC1 [cytosol]
(R-DME-68768)
0.547
2
UniProt:P40301 Prosalpha2
7
PROS25 [nucleoplasm]
(R-DME-216177)
PROS25 [cytosol]
(R-DME-206278)
Prosalpha2 [secretory granule lumen]
(R-DME-6803329)
Prosalpha2 [extracellular region]
(R-DME-6806506)
Prosalpha2 [ficolin-1-rich granule lumen]
(R-DME-6803285)
Prosalpha2 [nucleoplasm]
(R-DME-174345)
Prosalpha2 [cytosol]
(R-DME-68726)
0.547
3
UniProt:Q9XYN7 Prosbeta3
4
PROSbeta3 [nucleoplasm]
(R-DME-216230)
PROSbeta3 [cytosol]
(R-DME-206158)
Prosbeta3 [nucleoplasm]
(R-DME-174341)
Prosbeta3 [cytosol]
(R-DME-68747)
0.547
2
UniProt:Q9VJJ0 CG17331
4
CG17331 [nucleoplasm]
(R-DME-216116)
CG17331 [cytosol]
(R-DME-206285)
Prosbeta4 [nucleoplasm]
(R-DME-174335)
Prosbeta4 [cytosol]
(R-DME-68744)
0.547
2
UniProt:Q8IG84 Q8IG84
0.488
2
UniProt:Q9VC66 Q9VC66
0.488
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text