Reactome | PTPN6,PTPN11 [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-914049] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-389749] PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-389941] SHP-1 and SHP-2 bind pBTLA - Rattus norvegicus [Reaction:R-RNO-5684169] G6B binds PTPN6,PTPN11 - Rattus norvegicus [Reaction:R-RNO-909738] SHP1 and SHP2 bind the common beta chain - Rattus norvegicus [Reaction:R-RNO-389759] Interaction of SHP-1 or SHP-2 with phospho PD-1 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10134831
displayName	PTPN6,PTPN11 [cytosol]
hasMember	[EntityWithAccessionedSequence:R-RNO-197938] PTPN6 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-162563] PTPN11 [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-389744] PTPN6,PTPN11 [cytosol] - Homo sapiens
maxDepth	2
name	PTPN6,PTPN11 SHP-2,SHP-1 SHP1,SHP2
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-389744

(input)	[Reaction:R-RNO-5684169] G6B binds PTPN6,PTPN11 [Reaction:R-RNO-909738] SHP1 and SHP2 bind the common beta chain [Reaction:R-RNO-389941] SHP-1 and SHP-2 bind pBTLA [Reaction:R-RNO-389759] Interaction of SHP-1 or SHP-2 with phospho PD-1
(activeUnit)	[CatalystActivity:10145494] protein tyrosine phosphatase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] [CatalystActivity:10134834] protein tyrosine phosphatase activity of PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]
(hasComponent)	[Complex:R-RNO-914049] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] [Complex:R-RNO-914086] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] [Complex:R-RNO-389935] SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] [Complex:R-RNO-389749] PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] [Complex:R-RNO-5684187] G6B:PTPN6,PTPN11 [plasma membrane]
(inferredTo)	[DefinedSet:R-HSA-389744] PTPN6,PTPN11 [cytosol]

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