Reactome | Interaction of SHP-1 or SHP-2 with phospho PD-1

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Interaction of SHP-1 or SHP-2 with phospho PD-1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10134838
displayName	Interaction of SHP-1 or SHP-2 with phospho PD-1
eventOf	[Pathway:R-RNO-389948] Co-inhibition by PD-1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-389759] Interaction of SHP-1 or SHP-2 with phospho PD-1 - Homo sapiens
input	[Complex:R-RNO-389746] p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] [DefinedSet:R-RNO-389744] PTPN6,PTPN11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of SHP-1 or SHP-2 with phospho PD-1
output	[Complex:R-RNO-389749] PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]
precedingEvent	[Reaction:R-RNO-389762] Phosphorylation of PD-1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-389759
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-389948] Co-inhibition by PD-1
(precedingEvent)	[Reaction:R-RNO-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
(inferredTo)	[Reaction:R-HSA-389759] Interaction of SHP-1 or SHP-2 with phospho PD-1

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