Reactome | High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10145494] protein tyrosine phosphatase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-RNO-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144837
displayName	High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
hasComponent	[DefinedSet:R-RNO-913422] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] [DefinedSet:R-RNO-389744] PTPN6,PTPN11 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-914086] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] - Homo sapiens
maxDepth	7
name	High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2
producedByEvent	[Reaction:R-RNO-909738] SHP1 and SHP2 bind the common beta chain - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-914086
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB
(physicalEntity)	[CatalystActivity:10145494] protein tyrosine phosphatase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
(output)	[Reaction:R-RNO-909738] SHP1 and SHP2 bind the common beta chain
(inferredTo)	[Complex:R-HSA-914086] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]

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