Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PTPN6,PTPN11 [cytosol]
Stable Identifier
R-RNO-389744
Type
Set [DefinedSet]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
SHP-2,SHP-1, SHP1,SHP2
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
G6B binds PTPN6,PTPN11 (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
SYK autophosphorylates (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-inhibition by BTLA (Rattus norvegicus)
SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Co-inhibition by PD-1 (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Participants
members
PTPN6 [cytosol]
(Rattus norvegicus)
PTPN11 [cytosol]
(Rattus norvegicus)
Participates
as an input of
G6B binds PTPN6,PTPN11 (Rattus norvegicus)
SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)
SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)
as a component of
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
Inferred From
PTPN6,PTPN11 [cytosol]
(Homo sapiens)
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
