Reactome | MDM2 ubiquitinates DYRK2

Schema > Reaction > Entries

MDM2 ubiquitinates DYRK2 Show undefined attributes

catalystActivity	[CatalystActivity:10067329] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10067331
displayName	MDM2 ubiquitinates DYRK2
eventOf	[Pathway:R-MMU-6804756] Regulation of TP53 Activity through Phosphorylation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6798373] MDM2 ubiquitinates DYRK2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-3215037] DYRK2 [nucleoplasm] [DefinedSet:R-MMU-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MDM2 ubiquitinates DYRK2
output	[EntityWithAccessionedSequence:R-MMU-6798383] PolyUb-DYRK2 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6804741] MDM2 forms homo- or heterodimers - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6798373
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6804756] Regulation of TP53 Activity through Phosphorylation
(inferredTo)	[Reaction:R-HSA-6798373] MDM2 ubiquitinates DYRK2