Reactome | Stabilization of p53

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Stabilization of p53 Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098457
displayName	Stabilization of p53
eventOf	[Pathway:R-MMU-69563] p53-Dependent G1 DNA Damage Response - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-MMU-69560] Transcriptional activation of p53 responsive genes - Mus musculus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-5693609] ATM phosphorylates TP53 at S15 - Mus musculus [Reaction:R-MMU-69685] CHEK2 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6804955] ATM phosphorylates MDM2 - Mus musculus [Reaction:R-MMU-349455] Phosphorylation of MDM4 by ATM - Mus musculus [Reaction:R-MMU-349426] Phosphorylation of MDM4 by CHEK2 - Mus musculus [Reaction:R-MMU-6804741] MDM2 forms homo- or heterodimers - Mus musculus [Reaction:R-MMU-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Mus musculus [Reaction:R-MMU-5633460] MDM2 binds TP53 - Mus musculus [Reaction:R-MMU-6804879] MDM2 ubiquitinates TP53 - Mus musculus [Reaction:R-MMU-6793685] Ubiquitinated TP53 translocates to the cytosol - Mus musculus [Pathway:R-MMU-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Mus musculus
inferredFrom	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Stabilization of p53
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-69541
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-69563] p53-Dependent G1 DNA Damage Response
(precedingEvent)	[Pathway:R-MMU-69560] Transcriptional activation of p53 responsive genes
(inferredTo)	[Pathway:R-HSA-69541] Stabilization of p53

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