Reactome | Expression of EOMES in the primitive streak

Schema > BlackBoxEvent > Entries

Expression of EOMES in the primitive streak Show undefined attributes

authored	[InstanceEdit:1013049] May, B, 2010-11-12
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:452990] May, B, 2010-01-15
dbId	452353
displayName	Expression of EOMES in the primitive streak
edited	[InstanceEdit:1013049] May, B, 2010-11-12
eventOf	[Pathway:R-HSA-9754189] Germ layer formation at gastrulation - Homo sapiens
followingEvent	[Reaction:R-HSA-9733781] EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene - Homo sapiens [Reaction:R-HSA-9756671] EOMES and TBXT bind the NANOG gene - Homo sapiens [Reaction:R-HSA-9756670] EOMES and TBXT bind the POU5F1 (OCT4) gene - Homo sapiens [Reaction:R-HSA-9756661] EOMES and TBXT bind the SOX2 gene - Homo sapiens [Reaction:R-HSA-9823952] EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene - Homo sapiens [Reaction:R-HSA-9756666] EOMES and TBXT (T, Brachyury) bind the SNAI1 gene - Homo sapiens [Reaction:R-HSA-9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene - Homo sapiens [Reaction:R-HSA-9823966] EOMES, SMAD2,3, MIXL1 bind the GSC gene - Homo sapiens [Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9754479] Expression of Eomes in the primitive streak - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-2888969] EOMES gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:453026] Differences between human and mouse embryonic stem cells [LiteratureReference:9794976] Transcription factor binding dynamics during human ES cell differentiation [LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of EOMES in the primitive streak
output	[EntityWithAccessionedSequence:R-HSA-452232] EOMES [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9754480] p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:5163260] Negative gene expression regulation by 'POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9754487] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4:CTNNB1:TBPL2:FOXH1:SMAD3:POU5F1:NANOG:EOMES gene [nucleoplasm]'
regulationReference	[RegulationReference:9642739] Negative gene expression regulation by 'POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]' Core transcriptional regulatory circuitry in human embryonic stem cells
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9773645] Tam, Patrick P L, 2022-05-08 [InstanceEdit:9794593] Probst, Simone, 2022-07-18 [InstanceEdit:9796183] Zissel, Lea, 2022-07-18 [InstanceEdit:9796182] Salehin, Nazmus, 2022-05-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-452353
summation	[Summation:453075] The Eomesodermin (EOMES) gene is transcribed to yield mRNA a...
updateTrackers	[UpdateTracker:9846956] Update Tracker - [BlackBoxEvent:452353] Expression of EOMES in the primitive streak - v82:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846956] Update Tracker - [BlackBoxEvent:452353] Expression of EOMES in the primitive streak - v82:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-9733781] EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene [Reaction:R-HSA-9756671] EOMES and TBXT bind the NANOG gene [Reaction:R-HSA-9756670] EOMES and TBXT bind the POU5F1 (OCT4) gene [Reaction:R-HSA-9756661] EOMES and TBXT bind the SOX2 gene [Reaction:R-HSA-9823966] EOMES, SMAD2,3, MIXL1 bind the GSC gene [Reaction:R-HSA-9823952] EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene [Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene [Reaction:R-HSA-9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene [Reaction:R-HSA-9756666] EOMES and TBXT (T, Brachyury) bind the SNAI1 gene
(hasEvent)	[Pathway:R-HSA-9754189] Germ layer formation at gastrulation
(inferredTo)	[BlackBoxEvent:R-MMU-9754479] Expression of Eomes in the primitive streak

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