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Schema
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Entries
NLRX1 binds CHUK:IKBKB:IKBKG
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authored
[InstanceEdit:9758466] Shamovsky, Veronica, 2021-11-12
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:9749474] Shamovsky, Veronica, 2021-08-04
dbId
9749471
displayName
NLRX1 binds CHUK:IKBKB:IKBKG
edited
[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
eventOf
[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:162165] negative regulation of canonical NF-kappaB signal transduction
input
[Complex:R-HSA-168113] CHUK:IKBKB:IKBKG [cytosol]
[EntityWithAccessionedSequence:R-HSA-9749510] K63polyUb-NLRX1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9749512] NLRX1 negatively regulates TLR-induced NF-?B signaling by targeting TRAF6 and IKK
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
NLRX1 binds CHUK:IKBKB:IKBKG
NLRX1 binds activated IKK complex
negativePrecedingEvent
[NegativePrecedingEvent:9773822] CHUK, IKBKB and IKBKG form IKK complex
orthologousEvent
[Reaction:R-GGA-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Gallus gallus
[Reaction:R-XTR-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Xenopus tropicalis
[Reaction:R-DRE-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Danio rerio
[Reaction:R-BTA-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Bos taurus
[Reaction:R-CFA-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Canis familiaris
[Reaction:R-RNO-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Rattus norvegicus
[Reaction:R-MMU-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Mus musculus
output
[Complex:R-HSA-9749472] CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol]
precedingEvent
[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
releaseDate
2022-06-09
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05
[InstanceEdit:9773242] de Martin, R, 2022-05-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9749471
summation
[Summation:9757927] Nucleotide binding oligomerization domain (NOD)-like recepto...
systematicName
K63polyUb-NLRX1 binds p-S176,S180-CHUK:p-S177,S181-IKBKB:IKBKG
Referrals
(hasEvent)
[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling
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