Reactome | TRAF2,6 ubiquitinates NLRC5

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TRAF2,6 ubiquitinates NLRC5 Show undefined attributes

authored	[InstanceEdit:9758466] Shamovsky, Veronica, 2021-11-12
catalystActivity	[CatalystActivity:9750948] ubiquitin-protein transferase activity of TRAF2, TRAF6 [cytosol]
catalystActivityReference	[CatalystActivityReference:9750944] ubiquitin-protein transferase activity of TRAF2, TRAF6 [cytosol] Reversible ubiquitination shapes NLRC5 function and modulates NF-?B activation switch
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9750951] Shamovsky, Veronica, 2021-08-17
dbId	9750946
displayName	TRAF2,6 ubiquitinates NLRC5
edited	[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
eventOf	[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9750942] USP14 deubiquitinates NLRC5 - Homo sapiens
input	[Complex:R-HSA-9750228] CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9750928] Reversible ubiquitination shapes NLRC5 function and modulates NF-?B activation switch
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TRAF2,6 ubiquitinates NLRC5
negativePrecedingEvent	[NegativePrecedingEvent:9773819] USP14 deubiquitinates NLRC5
orthologousEvent	[BlackBoxEvent:R-GGA-9750946] TRAF2,6 ubiquitinates NLRC5 - Gallus gallus [BlackBoxEvent:R-XTR-9750946] TRAF2,6 ubiquitinates NLRC5 - Xenopus tropicalis [BlackBoxEvent:R-SSC-9750946] TRAF2,6 ubiquitinates NLRC5 - Sus scrofa [BlackBoxEvent:R-BTA-9750946] TRAF2,6 ubiquitinates NLRC5 - Bos taurus [BlackBoxEvent:R-CFA-9750946] TRAF2,6 ubiquitinates NLRC5 - Canis familiaris [BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5 - Rattus norvegicus [BlackBoxEvent:R-MMU-9750946] TRAF2,6 ubiquitinates NLRC5 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-168104] CHUK [cytosol] [EntityWithAccessionedSequence:R-HSA-168114] IKBKB [cytosol] [EntityWithAccessionedSequence:R-HSA-9750938] K63polyUb-NLRC5 [cytosol]
precedingEvent	[Reaction:R-HSA-9750226] NLRC5 binds IKBKB and CHUK - Homo sapiens
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05 [InstanceEdit:9773242] de Martin, R, 2022-05-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9750946
summation	[Summation:9750940] NOD-like receptor C5 (NLRC5) functions as negative regulator...

Referrals

(hasEvent)	[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling
(precedingEvent)	[NegativePrecedingEvent:9773820] TRAF2,6 ubiquitinates NLRC5 [NegativePrecedingEvent:9773815] TRAF2,6 ubiquitinates NLRC5 [NegativePrecedingEvent:9773818] TRAF2,6 ubiquitinates NLRC5 [NegativePrecedingEvent:9773821] TRAF2,6 ubiquitinates NLRC5 [BlackBoxEvent:R-HSA-9750942] USP14 deubiquitinates NLRC5