Reactome | Regulation of NF-kappa B signaling

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Regulation of NF-kappa B signaling Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225371
displayName	Regulation of NF-kappa B signaling
eventOf	[Pathway:R-RNO-445989] TAK1-dependent IKK and NF-kappa-B activation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9749505] LRRC14 binds IKBKB and CHUK - Rattus norvegicus [Reaction:R-RNO-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Rattus norvegicus [Reaction:R-RNO-9750226] NLRC5 binds IKBKB and CHUK - Rattus norvegicus [BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5 - Rattus norvegicus [BlackBoxEvent:R-RNO-9750942] USP14 deubiquitinates NLRC5 - Rattus norvegicus [Reaction:R-RNO-9761344] USP18 binds IKBKG within IKK complex - Rattus norvegicus [Reaction:R-RNO-9757954] N4BP1 binds IKBKG - Rattus norvegicus [BlackBoxEvent:R-RNO-9757951] CASP8 cleaves N4BP1 at D424, D490 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of NF-kappa B signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9758274
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-445989] TAK1-dependent IKK and NF-kappa-B activation
(inferredTo)	[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling

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