Reactome | N4BP1 binds IKBKG

Schema > Reaction > Entries

N4BP1 binds IKBKG Show undefined attributes

authored	[InstanceEdit:9758466] Shamovsky, Veronica, 2021-11-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9757934] Shamovsky, Veronica, 2021-11-05
dbId	9757954
displayName	N4BP1 binds IKBKG
edited	[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
eventOf	[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:162165] negative regulation of canonical NF-kappaB signal transduction
input	[EntityWithAccessionedSequence:R-HSA-168108] IKBKG [cytosol] [EntityWithAccessionedSequence:R-HSA-9757941] N4BP1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9757963] N4BP1 negatively regulates NF-?B by binding and inhibiting NEMO oligomerization
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	N4BP1 binds IKBKG
orthologousEvent	[Reaction:R-DME-9757954] N4BP1 binds IKBKG - Drosophila melanogaster [Reaction:R-GGA-9757954] N4BP1 binds IKBKG - Gallus gallus [Reaction:R-XTR-9757954] N4BP1 binds IKBKG - Xenopus tropicalis [Reaction:R-DRE-9757954] N4BP1 binds IKBKG - Danio rerio [Reaction:R-SSC-9757954] N4BP1 binds IKBKG - Sus scrofa [Reaction:R-BTA-9757954] N4BP1 binds IKBKG - Bos taurus [Reaction:R-CFA-9757954] N4BP1 binds IKBKG - Canis familiaris [Reaction:R-RNO-9757954] N4BP1 binds IKBKG - Rattus norvegicus [Reaction:R-MMU-9757954] N4BP1 binds IKBKG - Mus musculus
output	[Complex:R-HSA-9757950] IKBKG:N4BP1 [cytosol]
regulatedBy	[NegativeRegulation:9757966] Negative regulation by 'active caspase-8 [cytosol]'
regulationReference	[RegulationReference:9757925] Negative regulation by 'active caspase-8 [cytosol]' N4BP1 negatively regulates NF-?B by binding and inhibiting NEMO oligomerization
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05 [InstanceEdit:9773242] de Martin, R, 2022-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9757954
summation	[Summation:9757937] NEDD4-binding protein 1 (N4BP1) negatively regulates Toll-li...

Referrals

(hasEvent)

[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling