Reactome | Regulation of NF-kappa B signaling

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10913356
displayName	Regulation of NF-kappa B signaling
eventOf	[Pathway:R-DME-445989] TAK1-dependent IKK and NF-kappa-B activation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-9761344] USP18 binds IKBKG within IKK complex - Drosophila melanogaster [Reaction:R-DME-9757954] N4BP1 binds IKBKG - Drosophila melanogaster [BlackBoxEvent:R-DME-9757951] CASP8 cleaves N4BP1 at D424, D490 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of NF-kappa B signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9758274
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-445989] TAK1-dependent IKK and NF-kappa-B activation
(inferredTo)	[Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling

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