Reactome | NUMB [plasma membrane]

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NUMB [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-443669] CRMP-2:NUMB:alpha adaptin [plasma membrane] - Homo sapiens [Complex:R-HSA-5610562] NUMB:ITCH [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5610735] NUMB binds ITCH - Homo sapiens [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH - Homo sapiens
created	[InstanceEdit:443588] Garapati, P V, 2009-10-12
dbId	443595
displayName	NUMB [plasma membrane]
endCoordinate	651
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-443595] Numb [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-RNO-443595] Numb [plasma membrane] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-443595] NUMB [plasma membrane] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-443595] NUMB [plasma membrane] - Bos taurus [EntityWithAccessionedSequence:R-SSC-443595] NUMB [plasma membrane] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-443595] numb [plasma membrane] - Danio rerio [EntityWithAccessionedSequence:R-XTR-443595] numb [plasma membrane] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-443595] NUMB [plasma membrane] - Gallus gallus [GenomeEncodedEntity:R-DME-443595] Ghost homologue of NUMB [plasma membrane] - Drosophila melanogaster
markingReferences	[MarkerReference:9725583] NUMB [plasma membrane] Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis
maxDepth	1
modified	[InstanceEdit:549169] Garapati, P V, 2010-03-17
name	NUMB Protein numb homolog NUMB_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P49757] UniProt:P49757 NUMB
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-443595
startCoordinate	1

Referrals

(proteinMarker)	[Cell:R-HSA-9725559] keratinocyte stem cell of skin epidermis basal layer
(marker)	[MarkerReference:9725583] NUMB [plasma membrane] Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis
(hasComponent)	[Complex:R-HSA-443669] CRMP-2:NUMB:alpha adaptin [plasma membrane] [Complex:R-HSA-5610562] NUMB:ITCH [cytosol] [Complex:R-HSA-1911544] Ub-NOTCH1:NUMB:ITCH [plasma membrane] [Complex:R-HSA-1604458] NOTCH1:NUMB:ITCH [plasma membrane]
(input)	[Reaction:R-HSA-5610735] NUMB binds ITCH [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH

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