Reactome | JUNB- and NPM1-ALK-mediated GZMB gene expression

Schema > BlackBoxEvent > Entries

JUNB- and NPM1-ALK-mediated GZMB gene expression Show undefined attributes

authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:8857380] cytolytic granule lumen
created	[InstanceEdit:9851087] Rothfels, Karen, 2023-10-12
crossReference	[DatabaseIdentifier:12020842] Mondo:0020325
dbId	9851088
disease	[Disease:9699595] anaplastic large cell lymphoma
displayName	JUNB- and NPM1-ALK-mediated GZMB gene expression
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2976052] GZMB Gene [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9846146] The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances [LiteratureReference:9846015] Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease [LiteratureReference:9846083] NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma
maxDepth	1
modified	[InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	JUNB- and NPM1-ALK-mediated GZMB gene expression
output	[EntityWithAccessionedSequence:R-HSA-6807037] GZMB [cytolytic granule lumen]
precedingEvent	[Reaction:R-HSA-9851084] JUNB dimer binds GZMB promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9850980] Positive gene expression regulation by 'GZMB gene:JUNB dimer [nucleoplasm]'
regulationReference	[RegulationReference:9851027] Positive gene expression regulation by 'GZMB gene:JUNB dimer [nucleoplasm]' NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9851088
summation	[Summation:9850818] Granzyme B (GZMB) is a member of a family of 5 cytotoxic GZM...

Referrals

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[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer

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