Reactome | NPM1-ALK-dependent JUNB translation

Schema > BlackBoxEvent > Entries

NPM1-ALK-dependent JUNB translation Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9725346] Rothfels, Karen, 2021-03-29
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9725345
disease	[Disease:1500689] cancer
displayName	NPM1-ALK-dependent JUNB translation
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer - Homo sapiens
followingEvent	[Reaction:R-HSA-9851084] JUNB dimer binds GZMB promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9725326] JUNB mRNA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9725283] The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling
maxDepth	1
modified	[InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
name	NPM1-ALK-dependent JUNB translation
output	[EntityWithAccessionedSequence:R-HSA-2186795] JUNB [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9725342] NPM1-ALK-dependent JUNB gene transcription - Homo sapiens
regulatedBy	[PositiveRegulation:9725347] Positive regulation by 'p-5S-RPS6 [cytosol]'
regulationReference	[RegulationReference:9725348] Positive regulation by 'p-5S-RPS6 [cytosol]' The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9725345
summation	[Summation:9725325] In addition to transcriptional control, NPM-ALK regulates th...

Referrals

(hasEvent)	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer
(precedingEvent)	[Reaction:R-HSA-9851084] JUNB dimer binds GZMB promoter

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