Reactome | NPM1-ALK-dependent JUNB gene transcription

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NPM1-ALK-dependent JUNB gene transcription Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9725340] Rothfels, Karen, 2021-03-29
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9725342
disease	[Disease:1500689] cancer
displayName	NPM1-ALK-dependent JUNB gene transcription
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9725345] NPM1-ALK-dependent JUNB translation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2187294] JUNB gene [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9725283] The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling [LiteratureReference:9725277] The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms [LiteratureReference:9725249] NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma [LiteratureReference:9725264] The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma [LiteratureReference:9724958] The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis [LiteratureReference:9846136] The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas [LiteratureReference:9725240] Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes [LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology [LiteratureReference:9845929] Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B [LiteratureReference:9846083] NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma
maxDepth	1
modified	[InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
name	NPM1-ALK-dependent JUNB gene transcription
output	[EntityWithAccessionedSequence:R-HSA-9725326] JUNB mRNA [cytosol]
regulatedBy	[PositiveRegulation:9725343] Positive regulation by 'p-T,Y MAPK monomers and dimers [nucleoplasm]' [PositiveGeneExpressionRegulation:9725337] Positive gene expression regulation by 'NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm]'
regulationReference	[RegulationReference:9725637] Positive regulation by 'p-T,Y MAPK monomers and dimers [nucleoplasm]' The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling [RegulationReference:9725640] Positive regulation by 'NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm]' The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9725342
summation	[Summation:9725335] NPM-ALK is known to drive expression of AP1 transcription fa...
updateTrackers	[UpdateTracker:9853295] Update Tracker - [BlackBoxEvent:9725342] NPM1-ALK-dependent JUNB gene transcription - v87:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853295] Update Tracker - [BlackBoxEvent:9725342] NPM1-ALK-dependent JUNB gene transcription - v87:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer
(precedingEvent)	[BlackBoxEvent:R-HSA-9725345] NPM1-ALK-dependent JUNB translation

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