Reactome | JUNB dimer binds GZMB promoter

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JUNB dimer binds GZMB promoter Show undefined attributes

authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9851085] Rothfels, Karen, 2023-10-12
crossReference	[DatabaseIdentifier:12020842] Mondo:0020325
dbId	9851084
disease	[Disease:9699595] anaplastic large cell lymphoma
displayName	JUNB dimer binds GZMB promoter
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9851088] JUNB- and NPM1-ALK-mediated GZMB gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2976052] GZMB Gene [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-2186795] JUNB [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9845948] Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules [LiteratureReference:9845934] Anaplastic large cell lymphomas: a study of 75 pediatric patients [LiteratureReference:9846083] NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma
maxDepth	1
modified	[InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	JUNB dimer binds GZMB promoter
output	[Complex:R-HSA-9850873] GZMB gene:JUNB dimer [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9725345] NPM1-ALK-dependent JUNB translation - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9851084
summation	[Summation:9850796] ALK+ anaplastic large cell lymphomas (ALCL) contain cytotoxi...

Referrals

(hasEvent)	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer
(precedingEvent)	[BlackBoxEvent:R-HSA-9851088] JUNB- and NPM1-ALK-mediated GZMB gene expression

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