Reactome | AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter

Schema > Reaction > Entries

AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter Show undefined attributes

authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9851065] Rothfels, Karen, 2023-10-12
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9851064
disease	[Disease:1500689] cancer
displayName	AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9851137] STAT3-dependent DNMT1 gene expression - Homo sapiens
input	[Complex:R-HSA-9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5660405] DNMT1 gene [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9846132] STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes [LiteratureReference:9850777] NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells [LiteratureReference:9701299] IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
maxDepth	1
modified	[InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter
output	[Complex:R-HSA-9850875] AcK685-p-Y705, S727-STAT3 dimer:DNMT1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9851064
summation	[Summation:9850810] STAT3 binds to the promoter of DNMT1 to stimulate gene expre...

Referrals

(hasEvent)	[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer
(precedingEvent)	[BlackBoxEvent:R-HSA-9851137] STAT3-dependent DNMT1 gene expression

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