SHC1 is recruited to the full-length ALK receptor after acti...

created [InstanceEdit:9700152] Rothfels, Karen, 2020-09-14
dbId 9700153
displayName SHC1 is recruited to the full-length ALK receptor after acti...
modified [InstanceEdit:9851213] Rothfels, Karen, 2023-10-14
schemaClass Summation
text SHC1 is recruited to the full-length ALK receptor after activation (Motegi et al, 2004; Degoutin et al, 2007; Kuo et al, 2007). The p46 and p52 isoforms of SHC1 bind to ALK phospho-tyrosine 1507 in a manner that depends on ALK kinase activity (Degoutin et al, 2007). SHC recruitment contributes to activation of MAP kinase signaling and cellular proliferation downstream of ALK signaling, as well as neurite outgrowth and differentiation in PC-12 cells (Souttou et al, 2001; Motegi et al, 2004; Moog-Lutz et al, 2005; Gouzi et al, 2005; Degoutin et al, 2007; reveiwed in Turner and Alexander, 2006; Chiarle et al, 2009).
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