Reactome | SHC1-2,SHC1-3 [cytosol]

Schema > DefinedSet > Entries

SHC1-2,SHC1-3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9700015] ALK mutant dimers:SHC1 [cytosol] - Homo sapiens [Complex:R-HSA-9026491] BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9700190] ALK mutants bind SHC - Homo sapiens [Reaction:R-HSA-9700154] Active ALK binds SHC1 - Homo sapiens [Reaction:R-HSA-9026493] p-Y516 of p-5Y-NTRK2 recruits SHC1 - Homo sapiens [Reaction:R-HSA-9034862] Activated NTRK3 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654625] Activated FGFR3 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654573] Activated FGFR1 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654404] Activated FGFR2 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654425] Activated FGFR4 binds SHC1 - Homo sapiens
created	[InstanceEdit:1169459] May, B, 2011-01-19
dbId	1169480
displayName	SHC1-2,SHC1-3 [cytosol]
hasMember	[EntityWithAccessionedSequence:R-HSA-1169451] SHC1-3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1169488] SHC1-2 [cytosol] - Homo sapiens
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-1169451] Shc1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-1169451] Shc1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-1169451] SHC1 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-1169451] SHC1 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-1169451] SHC1 [cytosol] - Sus scrofa [GenomeEncodedEntity:R-DRE-1169480] Ghost homologue of SHC1-2,SHC1-3 [cytosol] - Danio rerio [GenomeEncodedEntity:R-XTR-1169480] Ghost homologue of SHC1-2,SHC1-3 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-1169451] SHC1 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-1169451] Shc [cytosol] - Drosophila melanogaster
literatureReference	[LiteratureReference:1169447] B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins
maxDepth	2
modified	[InstanceEdit:9028345] Orlic-Milacic, Marija, 2017-11-07
name	SHC1-2,SHC1-3 SHC1 p46,p52 SHC1 p46 and p52
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1169480
summation	[Summation:1169593] SHC1 isoforms p46 and p52 are found in B cells (Smit et al. ...
updateTrackers	[UpdateTracker:9898189] Update Tracker - [DefinedSet:1169480] SHC1-2,SHC1-3 [cytosol] - v63:[addName] [UpdateTracker:9889113] Update Tracker - [DefinedSet:1169480] SHC1-2,SHC1-3 [cytosol] - v48:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9898189] Update Tracker - [DefinedSet:1169480] SHC1-2,SHC1-3 [cytosol] - v63:[addName] [UpdateTracker:9889113] Update Tracker - [DefinedSet:1169480] SHC1-2,SHC1-3 [cytosol] - v48:[modifyName]
(hasComponent)	[Complex:R-HSA-9700015] ALK mutant dimers:SHC1 [cytosol] [Complex:R-HSA-9699970] Active ALK:SHC1 [plasma membrane] [Complex:R-HSA-9026491] BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] [Complex:R-HSA-9034865] NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane] [Complex:R-HSA-5654300] Activated FGFR3:SHC1 [plasma membrane] [Complex:R-HSA-5654258] Activated FGFR1:SHC1 [plasma membrane] [Complex:R-HSA-5654279] Activated FGFR2:SHC1 [plasma membrane] [Complex:R-HSA-5654320] Activated FGFR4:SHC1 [plasma membrane]
(input)	[Reaction:R-HSA-9700190] ALK mutants bind SHC [Reaction:R-HSA-9700154] Active ALK binds SHC1 [Reaction:R-HSA-9026493] p-Y516 of p-5Y-NTRK2 recruits SHC1 [Reaction:R-HSA-9034862] Activated NTRK3 binds SHC1 [Reaction:R-HSA-5654625] Activated FGFR3 binds SHC1 [Reaction:R-HSA-5654573] Activated FGFR1 binds SHC1 [Reaction:R-HSA-5654404] Activated FGFR2 binds SHC1 [Reaction:R-HSA-5654425] Activated FGFR4 binds SHC1

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