Active ALK binds SHC1

Stable Identifier
Homo sapiens
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SHC1 is recruited to the ALK receptor after activation (Motegi et al, 2004; Degoutin et al, 2007; Kuo et al, 2007). The p46 and p52 isoforms of SHC1 bind to ALK phospho-tyrosine 1507 in a manner that depends on ALK kinase activity (Degoutin et al, 2007). SHC recruitment contributes to activation of MAP kinase signaling and cellular proliferation downstream of ALK signaling, as well as neurite outgrowth and differentiation in PC-12 cells (Souttou et al, 2001; Motegi et al, 2004; Moog-Lutz et al, 2005; Gouzi et al, 2005; Degoutin et al, 2007; reveiwed in Chiarle et al, 2009).

Literature References
PubMed ID Title Journal Year
15226403 ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

Kotani, M, Motegi, A, Sakuraba, H, Fujimoto, J, Yamamoto, T

J. Cell. Sci. 2004
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
16317043 Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells

Vigny, M, Brunet-de Carvalho, N, Moog-Lutz, C, Gouzi, JY

J Cell Sci 2005
11121404 Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway

Carvalho, NB, Raulais, D, Vigny, M, Souttou, B

J. Biol. Chem. 2001
16878150 Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase

Kuo, AH, Stoica, GE, Riegel, AT, Wellstein, A

Oncogene 2007
17274988 ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Vigny, M, Degoutin, J, Gouzi, JY

FEBS Lett. 2007
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