Reactome | AKT-phosphorylated FOXO3 translocates to cytosol

Schema > BlackBoxEvent > Entries

AKT-phosphorylated FOXO3 translocates to cytosol Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9699582] Rothfels, Karen, 2020-09-14
dbId	9699581
displayName	AKT-phosphorylated FOXO3 translocates to cytosol
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-199289] p-T32,S253,S315-FOXO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9699298] FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins [LiteratureReference:9624501] A brief introduction to FOXOlogy [LiteratureReference:9699307] FoxO transcription factors in cancer metabolism [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	AKT-phosphorylated FOXO3 translocates to cytosol
orthologousEvent	[BlackBoxEvent:R-CEL-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Caenorhabditis elegans [BlackBoxEvent:R-DME-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Drosophila melanogaster [BlackBoxEvent:R-XTR-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Xenopus tropicalis [BlackBoxEvent:R-DRE-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Danio rerio [BlackBoxEvent:R-SSC-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Sus scrofa [BlackBoxEvent:R-BTA-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Bos taurus [BlackBoxEvent:R-CFA-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Canis familiaris [BlackBoxEvent:R-RNO-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Rattus norvegicus [BlackBoxEvent:R-MMU-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9614413] p-T32,S253,S315-FOXO3 [cytosol]
precedingEvent	[Reaction:R-HSA-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9699581
summation	[Summation:9699399] AKT-mediated phosphorylation of FOXO3 downstream of FLT3 and...

Referrals

(hasEvent)

[Pathway:R-HSA-9607240] FLT3 Signaling