Reactome | AKT phosphorylates FOXO3 downstream of FLT3

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AKT phosphorylates FOXO3 downstream of FLT3 Show undefined attributes

catalystActivity	[CatalystActivity:10669144] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10734422
displayName	AKT phosphorylates FOXO3 downstream of FLT3
eventOf	[Pathway:R-DME-9607240] FLT3 Signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DME-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-DME-199305] foxo [nucleoplasm]
isInDisease	false
isInferred	true
name	AKT phosphorylates FOXO3 downstream of FLT3
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-DME-199289] phospho-foxo [nucleoplasm]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9699579
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9607240] FLT3 Signaling
(precedingEvent)	[BlackBoxEvent:R-DME-9699581] AKT-phosphorylated FOXO3 translocates to cytosol
(inferredTo)	[Reaction:R-HSA-9699579] AKT phosphorylates FOXO3 downstream of FLT3