Reactome | tandutinib-sensitive FLT3 mutants [plasma membrane]

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tandutinib-sensitive FLT3 mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699540
disease	[Disease:1500689] cancer
displayName	tandutinib-sensitive FLT3 mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9696044] FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9696033] FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9696042] FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9696038] FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLF [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682290] FLT3 D835A [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682297] FLT3 D835E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682304] FLT3 D835H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682321] FLT3 D835N [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9695714] FLT3 I836del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699438] FLT3 L601_L610dup [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699445] FLT3 V592_E598dup [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9696032] FLT3 R595_L601dup [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9696041] FLT3 E598_Y599insFDFREYE [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518 [LiteratureReference:9699231] CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML) [LiteratureReference:9699340] Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation [LiteratureReference:9699359] Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
maxDepth	2
memberOf	[DefinedSet:R-HSA-9702524] type II TKI sensitive FLT3 mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832472] Orlic-Milacic, Marija, 2023-04-01
name	tandutinib-sensitive FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699540
updateTrackers	[UpdateTracker:9905481] Update Tracker - [DefinedSet:9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] - v85:[add_removeHasMember]

Referrals

(updatedInstance)	[UpdateTracker:9905481] Update Tracker - [DefinedSet:9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] - v85:[add_removeHasMember]
(hasMember)	[DefinedSet:R-HSA-9702524] type II TKI sensitive FLT3 mutants [plasma membrane]

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