Reactome | FLT3 D835H [plasma membrane]

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FLT3 D835H [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9682341] FLT3 D835H dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9682307] Rothfels, Karen, 2020-04-08
crossReference	[DatabaseIdentifier:9682306] COSMIC:COSV54042636 [DatabaseIdentifier:9682305] COSMIC:COSM29483
dbId	9682304
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 D835H [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9682308] L-aspartic acid 835 replaced with L-histidine
inDisease	true
literatureReference	[LiteratureReference:9682272] Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies [LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
memberOf	[DefinedSet:R-HSA-9699534] pexidartinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699527] ponatinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699528] sunitinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699530] sorafenib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699535] crenolanib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9695707] Rothfels, Karen, 2020-07-15
name	FLT3 D835H STK-1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9682304
startCoordinate	27

Referrals

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[Complex:R-HSA-9682341] FLT3 D835H dimer [plasma membrane]

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