Reactome | FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9696080] FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9696080] FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9696040] Rothfels, Karen, 2020-07-17
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9696042
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9696016] Replacement of residues 610 to 611 by LCSSDNEYFYVDFREYEYDLKWEFPRENLE
inDisease	true
literatureReference	[LiteratureReference:9696007] FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model [LiteratureReference:9697896] Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
maxDepth	1
memberOf	[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832501] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL Npos Mut1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9696042
startCoordinate	27
updateTrackers	[UpdateTracker:9905315] Update Tracker - [EntityWithAccessionedSequence:9696042] FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane] - v85:[removeHasModifiedResidue]

Referrals

(updatedInstance)	[UpdateTracker:9905315] Update Tracker - [EntityWithAccessionedSequence:9696042] FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane] - v85:[removeHasModifiedResidue]
(hasMember)	[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9696080] FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL dimer [plasma membrane]

Cite Us!