Reactome | FLT3 R595_L601dup [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

FLT3 R595_L601dup [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9696074] FLT3 R595_L601dup dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9696074] FLT3 R595_L601dup dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9696040] Rothfels, Karen, 2020-07-17
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9832470] COSMIC:COSV54045432
dbId	9696032
deleted	[Deleted:9832476] Deletion of instance: 9696048
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 R595_L601dup [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentInsertionModification:9696029] Insertion of residues 595 to 601 at 602 from UniProt:P36888 FLT3
inDisease	true
literatureReference	[LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways [LiteratureReference:9649425] Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD [LiteratureReference:9696007] FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
maxDepth	1
memberOf	[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832472] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 R595_L601dup ITD3 N51 W51
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9696032
startCoordinate	27
updateTrackers	[UpdateTracker:9905376] Update Tracker - [EntityWithAccessionedSequence:9696032] FLT3 R595_L601dup [plasma membrane] - v85:[addLiteratureReference, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905376] Update Tracker - [EntityWithAccessionedSequence:9696032] FLT3 R595_L601dup [plasma membrane] - v85:[addLiteratureReference, modifyName]
(replacementInstances)	[Deleted:9832476] Deletion of instance: 9696048
(hasMember)	[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9696074] FLT3 R595_L601dup dimer [plasma membrane]