tandutinib-sensitive FLT3 mutants [plasma membrane]

Stable Identifier
Set [DefinedSet]
Homo sapiens
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15256420 Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

Gilliland, DG, Lokker, NA, Curley, DP, Clark, JJ, Giese, NA, Yu, JC, Cools, J

Blood 2004
12124172 CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)

Gilliland, DG, Boulton, CL, Kelly, LM, Duclos, N, Scarborough, RM, Li, J, Neuberg, D, Amaral, SM, Sullivan, CM, Hollenbach, S, Pandey, A, Lokker, NA, Williams, I, Apatira, M, Abe, K, Curley, DP, Giese, NA, Yu, JC

Cancer Cell 2002
22354205 Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Pearson, AD, Avery, S, Workman, P, Faisal, A, Mair, D, Atrash, B, Blagg, J, Bavetsias, V, Linardopoulos, S, Mirabella, F, Valenti, M, Eccles, SA, Moore, AS, de Haven Brandon, A, Sun, C, Swansbury, J, Gonzalez de Castro, D, Raynaud, FI

Leukemia 2012
27132990 Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation

Huang, A, Liu, K, Wen, S, Huang, P, Liu, D, Hu, Y, Garcia-Manero, G, Ju, HQ, Zhan, G

Cancer Lett. 2016
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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