Reactome | FLT3 I836del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9695759] FLT3 I836del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695759] FLT3 I836del dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9695711] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9695697] COSMIC:COSV54043228 [DatabaseIdentifier:9695686] COSMIC:COSM24603
dbId	9695714
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 I836del [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentDeletionModification:9695641] Deletion of residues 836 to 836
inDisease	true
literatureReference	[LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
maxDepth	1
memberOf	[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane] - Homo sapiens
name	FLT3 I836del STK-1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9695714
startCoordinate	27

(hasMember)	[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9695759] FLT3 I836del dimer [plasma membrane]

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