3CLp cleaves pp1ab

Stable Identifier
R-HSA-9694732
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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3CLp cleaves pp1ab
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Main protease of SARS-CoV-2 (3CLpro, nsp5) cleaves all cleavage sites of pp1a and ppa1b starting with nsp4/5, thus cleaving itself, and all the cytosolic RTC proteins. This is essential for maturation of the viral replicase complex and for making it fully functional (Du et al, 2021).
Literature References
PubMed ID Title Journal Year
34437808 Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

Hinshaw, SM, Windsor, IW, Namchuk, MN, MacDonald, EA, Harrison, SC, Frey, G

ACS Infect Dis 2021
34847508 Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication

Peng, X, Guo, D, Zheng, K, Xia, W, Wang, N, Cao, L, Yu, T, Xie, Y, Shao, Q, Gao, M, Zou, Y, Du, L, Fang, Q, Pan, JA, Zhao, B

Redox Biol 2021
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of 3CLp dimer [cytosol]

Physical Entity
3CLp dimer [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Activity
cysteine-type endopeptidase activity (GO:0004197)
This event is regulated
Negatively by
Regulator
3CLp dimer:3CLp inhibitors [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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