Reactome | pp1ab-nsp12 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:9765942] protein guanylyltransferase activity of pp1ab-nsp12 [cytosol] [CatalystActivity:9792634] mRNA guanylyltransferase activity of pp1ab-nsp12 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-COV-9771682] nsp12:2Fe4S4 [cytosol] - Severe acute respiratory syndrome coronavirus 2
consumedByEvent	[BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors - Homo sapiens
created	[InstanceEdit:9682059] D'Eustachio, Peter, 2020-04-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9682057
deleted	[Deleted:9696782] Deletion of instance: 9694547
disease	[Disease:9683912] COVID-19
displayName	pp1ab-nsp12 [cytosol]
endCoordinate	5324
inDisease	true
maxDepth	1
modified	[InstanceEdit:9696779] Orlic-Milacic, Marija, 2020-07-29
name	pp1ab-nsp12 pp1ab-RdRNP RNA-directed RNA polymerase
producedByEvent	[Reaction:R-HSA-9694732] 3CLp cleaves pp1ab - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P0DTD1] UniProt:P0DTD1 rep
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
stId	R-COV-9682057
startCoordinate	4393

(replacementInstances)	[Deleted:9696782] Deletion of instance: 9694547
(physicalEntity)	[CatalystActivity:9765942] protein guanylyltransferase activity of pp1ab-nsp12 [cytosol] [CatalystActivity:9792634] mRNA guanylyltransferase activity of pp1ab-nsp12 [cytosol]
(input)	[BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors
(activeUnit)	[CatalystActivity:9694369] RNA-directed RNA polymerase activity of SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] [CatalystActivity:9694270] RNA-directed RNA polymerase activity of SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] [CatalystActivity:9694509] RNA-directed RNA polymerase activity of SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] [CatalystActivity:9713654] RNA-directed RNA polymerase activity of SARS-CoV-2 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
(output)	[Reaction:R-HSA-9694732] 3CLp cleaves pp1ab
(hasComponent)	[Complex:R-COV-9771682] nsp12:2Fe4S4 [cytosol]

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