Reactome | OPTN [cytosol]

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9828198] OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] - Homo sapiens [Complex:R-HSA-9823815] OPTN:CASP8 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex - Homo sapiens [Reaction:R-HSA-9823816] OPTN binds CASP8 - Homo sapiens [Reaction:R-HSA-9823934] OPTN binds TBK1 within the activated TLR4 complex - Homo sapiens [Reaction:R-HSA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Homo sapiens [Reaction:R-HSA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Homo sapiens
created	[InstanceEdit:9687934] Varusai, Thawfeek, 2020-05-13
dbId	9687907
displayName	OPTN [cytosol]
endCoordinate	577
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-9687907] OPTN [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-9687907] OPTN [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-9687907] OPTN [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-9687907] OPTN [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-9687907] OPTN [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-9687907] OPTN [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-9687907] optn [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-9687907] OPTN [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-9687907] OPTN [cytosol] - Drosophila melanogaster
maxDepth	1
name	OPTN Optineurin Huntingtin-interacting protein 7
referenceEntity	[ReferenceGeneProduct:uniprot:Q96CV9] UniProt:Q96CV9 OPTN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9687907
startCoordinate	1

(activeUnit)	[PositiveRegulation:9828206] Positive regulation by 'OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]' [NegativeRegulation:9820386] Negative regulation by 'TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]' [NegativeRegulation:9828541] Negative regulation by 'OPTN:CASP8 [cytosol]' [PositiveRegulation:9823947] Positive regulation by 'OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane]'
(hasComponent)	[Complex:R-HSA-9828198] OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] [Complex:R-HSA-9793672] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] [Complex:R-HSA-9823815] OPTN:CASP8 [cytosol] [Complex:R-HSA-9823935] OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] [Complex:R-HSA-9824896] TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] [Complex:R-HSA-9824891] p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane]
(input)	[Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex [Reaction:R-HSA-9823816] OPTN binds CASP8 [Reaction:R-HSA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex [Reaction:R-HSA-9823934] OPTN binds TBK1 within the activated TLR4 complex [Reaction:R-HSA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins

OPTN [cytosol] Show undefined attributes

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