Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
OPTN binds TBK1 within the activated TLR4 complex
Show undefined attributes
Go to Details
authored
[InstanceEdit:9823790] Shamovsky, Veronica, 2023-01-10
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
created
[InstanceEdit:9823930] Shamovsky, Veronica, 2023-01-12
dbId
9823934
displayName
OPTN binds TBK1 within the activated TLR4 complex
edited
[InstanceEdit:9863317] Shamovsky, Veronica, 2024-02-28
eventOf
[Pathway:R-HSA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7 - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9687907] OPTN [cytosol]
[Complex:R-HSA-9823899] TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9824046] Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon ?
[LiteratureReference:9827948] The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
OPTN binds TBK1 within the activated TLR4 complex
orthologousEvent
[Reaction:R-GGA-9823934] OPTN binds TBK1 within the activated TLR4 complex - Gallus gallus
[Reaction:R-DRE-9823934] OPTN binds TBK1 within the activated TLR4 complex - Danio rerio
[Reaction:R-SSC-9823934] OPTN binds TBK1 within the activated TLR4 complex - Sus scrofa
[Reaction:R-BTA-9823934] OPTN binds TBK1 within the activated TLR4 complex - Bos taurus
[Reaction:R-CFA-9823934] OPTN binds TBK1 within the activated TLR4 complex - Canis familiaris
[Reaction:R-RNO-9823934] OPTN binds TBK1 within the activated TLR4 complex - Rattus norvegicus
[Reaction:R-MMU-9823934] OPTN binds TBK1 within the activated TLR4 complex - Mus musculus
output
[Complex:R-HSA-9823935] OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane]
precedingEvent
[Reaction:R-HSA-9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Homo sapiens
releaseDate
2024-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9863305] Muniti?, Ivana, 2024-02-28
[InstanceEdit:9863304] Franjki?, Toni, 2024-02-28
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9823934
summation
[Summation:9823933] Optineurin (OPTN), also known as FIP2, HYPL, FIP-2, TFIIIA-I...
Referrals
(hasEvent)
[Pathway:R-HSA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text