Reactome | OPTN [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DRE-9793672] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] - Danio rerio [Complex:R-DRE-9823815] OPTN:CASP8 [cytosol] - Danio rerio
consumedByEvent	[Reaction:R-DRE-9823816] OPTN binds CASP8 - Danio rerio [Reaction:R-DRE-9823934] OPTN binds TBK1 within the activated TLR4 complex - Danio rerio [Reaction:R-DRE-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10642886
displayName	OPTN [cytosol]
endCoordinate	577
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-9687907] OPTN [cytosol] - Homo sapiens
maxDepth	1
name	OPTN Q5RI56
referenceEntity	[ReferenceGeneProduct:uniprot:Q5RI56] UniProt:Q5RI56
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68323] Danio rerio
stId	R-DRE-9687907
startCoordinate	1

(input)	[Reaction:R-DRE-9823816] OPTN binds CASP8 [Reaction:R-DRE-9823934] OPTN binds TBK1 within the activated TLR4 complex [Reaction:R-DRE-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins
(hasComponent)	[Complex:R-DRE-9793672] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] [Complex:R-DRE-9823815] OPTN:CASP8 [cytosol] [Complex:R-DRE-9823935] OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] [Complex:R-DRE-9824896] TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] [Complex:R-DRE-9824891] p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-9687907] OPTN [cytosol]