Reactome | OPTN binds polyUb-RIPK1 within the TNFR1 complex

Schema > Reaction > Entries

OPTN binds polyUb-RIPK1 within the TNFR1 complex Show undefined attributes

authored	[InstanceEdit:9793675] Shamovsky, Veronica, 2022-06-23
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9793675] Shamovsky, Veronica, 2022-06-23
dbId	9793680
displayName	OPTN binds polyUb-RIPK1 within the TNFR1 complex
edited	[InstanceEdit:9829016] Shamovsky, Veronica, 2023-02-21
eventOf	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9824874] OPTN recruits CYLD to the TNFR1 complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9687907] OPTN [cytosol] [DefinedSet:R-HSA-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9793663] Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP [LiteratureReference:9823770] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	OPTN binds polyUb-RIPK1 within the TNFR1 complex
orthologousEvent	[Reaction:R-SSC-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Sus scrofa [Reaction:R-BTA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Bos taurus [Reaction:R-CFA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Canis familiaris [Reaction:R-RNO-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Rattus norvegicus [Reaction:R-MMU-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Mus musculus
output	[Complex:R-HSA-9793672] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Homo sapiens
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9796128] D'Eustachio, Peter, 2022-08-05 [InstanceEdit:9796552] Tu, Hailin, 2022-08-10 [InstanceEdit:9828415] Muniti?, Ivana, 2023-02-14 [InstanceEdit:9830259] Franjki?, Toni, 2023-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9793680
summation	[Summation:9823782] Optineurin (OPTN, also called FIP2 and NRP), is a multifunct...
updateTrackers	[UpdateTracker:9846668] Update Tracker - [Reaction:9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - v84:[addLiteratureReference, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9846668] Update Tracker - [Reaction:9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - v84:[addLiteratureReference, add_removeSummation]
(precedingEvent)	[Reaction:R-HSA-9824874] OPTN recruits CYLD to the TNFR1 complex
(hasEvent)	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling