Recruitment of PLCgamma to membrane due to FCGR3A effect

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Leishmania major
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PLCgamma (PLCG) is recruited to FCGR and the phosphorylated Y342 and Y346 in SYK have been reported to be involved in the interaction of PLCG (Law et al. 1996). PLCG accumulates at the phagocytic cup during FCGR, but the exact role of PLCG in the regulation of phagocytosis is not clear. It may be involved in FCGR signaling by activating PKC through DAG production (Garcia-Garcia & Rosales 2002 )

Literature References
PubMed ID Title Journal Year
8657103 Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

Law, CL, Chandran, KA, Sidorenko, SP, Clark, EA

Mol Cell Biol 1996
7517665 Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils

Dusi, S, Donini, M, Della Bianca, V, Rossi, F

Biochem Biophys Res Commun 1994
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
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