Reactome | Regulation of FOXO transcriptional activity by acetylation

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Regulation of FOXO transcriptional activity by acetylation Show undefined attributes

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
created	[InstanceEdit:9617628] Orlic-Milacic, Marija, 2018-08-29
dbId	9617629
displayName	Regulation of FOXO transcriptional activity by acetylation
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9614085] FOXO-mediated transcription - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9617660] ROS oxidize FOXO4 cysteine residues - Homo sapiens [Reaction:R-HSA-9617683] EP300,CREBBP bind SOH-C481-FOXO4 - Homo sapiens [Reaction:R-HSA-9617735] TXN disrupts FOXO4 complex with EP300 - Homo sapiens [Reaction:R-HSA-9617758] EP300,CREBBP acetylate FOXO4 - Homo sapiens [Reaction:R-HSA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Homo sapiens [Reaction:R-HSA-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Homo sapiens [Reaction:R-HSA-9626928] CREBBP binds FOXO1 - Homo sapiens [Reaction:R-HSA-9626945] CREBBP acetylates FOXO1 - Homo sapiens [Reaction:R-HSA-9626962] SIRT1 deacetylates FOXO1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9617630] Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha) [LiteratureReference:9620508] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [LiteratureReference:9617662] Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity [LiteratureReference:9622897] SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress [LiteratureReference:9622894] SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage [LiteratureReference:9626714] Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity [LiteratureReference:9626722] Mammalian SIRT1 represses forkhead transcription factors [LiteratureReference:9626711] Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes [LiteratureReference:9626717] Posttranslational modifications control FoxO3 activity during denervation
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Regulation of FOXO transcriptional activity by acetylation
orthologousEvent	[Pathway:R-CEL-9617629] Regulation of FOXO transcriptional activity by acetylation - Caenorhabditis elegans [Pathway:R-DME-9617629] Regulation of FOXO transcriptional activity by acetylation - Drosophila melanogaster [Pathway:R-GGA-9617629] Regulation of FOXO transcriptional activity by acetylation - Gallus gallus [Pathway:R-XTR-9617629] Regulation of FOXO transcriptional activity by acetylation - Xenopus tropicalis [Pathway:R-DRE-9617629] Regulation of FOXO transcriptional activity by acetylation - Danio rerio [Pathway:R-SSC-9617629] Regulation of FOXO transcriptional activity by acetylation - Sus scrofa [Pathway:R-BTA-9617629] Regulation of FOXO transcriptional activity by acetylation - Bos taurus [Pathway:R-CFA-9617629] Regulation of FOXO transcriptional activity by acetylation - Canis familiaris [Pathway:R-RNO-9617629] Regulation of FOXO transcriptional activity by acetylation - Rattus norvegicus [Pathway:R-MMU-9617629] Regulation of FOXO transcriptional activity by acetylation - Mus musculus
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9617629
summation	[Summation:9617634] Oxidative stress induces acetylation of FOXO transcription f...

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(hasEvent)

[Pathway:R-HSA-9614085] FOXO-mediated transcription

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