Regulation of FOXO transcriptional activity by acetylation

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Oxidative stress induces acetylation of FOXO transcription factors, which changes the preference of FOXO transcription factors for target DNA sequences. Histone deacetylases SIRT1 and SIRT3 deacetylate FOXO transcription factors (Brunet et al. 2004, Daitoku et al. 2004, Motta et al. 2004, Dansen et al. 2009, Kim et al. 2010, Tseng et al. 2013, reviewed by Hisahara et al. 2005).
Acetylation can also regulate FOXO localization, overriding phosphorylation (Frescas et al. 2005, Bertaggia et al. 2012).

Literature References
PubMed ID Title Journal Year
22094330 Posttranslational modifications control FoxO3 activity during denervation

Coletto, L, Sandri, M, Bertaggia, E

Am. J. Physiol., Cell Physiol. 2012
14976264 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Sinclair, DA, Jedrychowski, MP, Greenberg, ME, Brunet, A, Alt, FW, Gygi, SP, Hu, LS, Ross, SE, Lin, Y, Cohen, HY, Sweeney, LB, Chua, KF, Sturgill, JF, Mostoslavsky, R, Tran, H, Cheng, HL, Greer, PL

Science 2004
23665396 SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

Tseng, AH, Shieh, SS, Wang, DL

Free Radic. Biol. Med. 2013
19648934 Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

van Leenen, D, Burgering, BM, Yodoi, J, van Triest, MH, Holstege, FC, Meppelink, A, de Keizer, PL, Szypowska, A, Koerkamp, MG, Smits, LM, Brenkman, AB, Dansen, TB

Nat. Chem. Biol. 2009
16006743 Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha)

Chiba, S, Horio, Y, Hisahara, S, Matsumoto, H

J. Pharmacol. Sci. 2005
15220471 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

Matsuzaki, H, Ohshima, T, Daitoku, H, Aratani, S, Miyagishi, M, Fukamizu, A, Hatta, M, Nakajima, T

Proc. Natl. Acad. Sci. U.S.A. 2004
15788402 Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

Frescas, D, Accili, D, Valenti, L

J. Biol. Chem. 2005
20129246 SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Muldoon-Jacobs, K, Gius, D, Singh, KK, Park, SH, Spitz, DR, Owens, KM, Vassilopoulos, A, Aykin-Burns, N, Ozden, O, Savage, J, Pennington, JD, Abdulkadir, SA, Patel, K, Deng, CX, Bisht, KS, Nguyen, P, van der Meer, R, Kim, HS

Cancer Cell 2010
14980222 Mammalian SIRT1 represses forkhead transcription factors

Guarente, L, Gu, W, Motta, MC, Lemieux, M, Bultsma, Y, Kamel, C, Chen, D, McBurney, M, Divecha, N

Cell 2004
Orthologous Events
Cite Us!