| created | [InstanceEdit:9617628] Orlic-Milacic, Marija, 2018-08-29 |
| dbId | 9617634 |
| displayName | Oxidative stress induces acetylation of FOXO transcription f... |
| modified | [InstanceEdit:9626727] Orlic-Milacic, Marija, 2018-10-29 |
| schemaClass | Summation |
| text |
Oxidative stress induces acetylation of FOXO transcription factors, which changes the preference of FOXO transcription factors for target DNA sequences. Histone deacetylases SIRT1 and SIRT3 deacetylate FOXO transcription factors (Brunet et al. 2004, Daitoku et al. 2004, Motta et al. 2004, Dansen et al. 2009, Kim et al. 2010, Tseng et al. 2013, reviewed by Hisahara et al. 2005). Acetylation can also regulate FOXO localization, overriding phosphorylation (Frescas et al. 2005, Bertaggia et al. 2012). |
| (summation) |
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