Reactome | Regulation of FOXO transcriptional activity by acetylation

Schema > Pathway > Entries

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650532
displayName	Regulation of FOXO transcriptional activity by acetylation
eventOf	[Pathway:R-DRE-9614085] FOXO-mediated transcription - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Danio rerio [Reaction:R-DRE-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Danio rerio
inferredFrom	[Pathway:R-HSA-9617629] Regulation of FOXO transcriptional activity by acetylation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of FOXO transcriptional activity by acetylation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-9617629
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-9614085] FOXO-mediated transcription
(inferredTo)	[Pathway:R-HSA-9617629] Regulation of FOXO transcriptional activity by acetylation

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