Reactome | Activated TLR4:TICAM1 recruits TRAF6

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Activated TLR4:TICAM1 recruits TRAF6 Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
dbId	936985
displayName	Activated TLR4:TICAM1 recruits TRAF6
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Homo sapiens
input	[Complex:R-HSA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:500568] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway [LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 [LiteratureReference:169969] Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death [LiteratureReference:208040] Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain [LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated TLR4:TICAM1 recruits TRAF6
orthologousEvent	[Reaction:R-GGA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Gallus gallus [Reaction:R-SSC-936985] Activated TLR4:TICAM1 recruits TRAF6 - Sus scrofa [Reaction:R-BTA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Bos taurus [Reaction:R-CFA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Canis familiaris [Reaction:R-RNO-936985] Activated TLR4:TICAM1 recruits TRAF6 - Rattus norvegicus [Reaction:R-MMU-936985] Activated TLR4:TICAM1 recruits TRAF6 - Mus musculus
output	[Complex:R-HSA-936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-HSA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Homo sapiens [Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-2559573] Negative regulation by 'SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-936985
summation	[Summation:446616] TRAF6 is recruited to the N-terminal domain of TICAM1 and th...
updateTrackers	[UpdateTracker:9780719] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v62:[add_removeInput] [UpdateTracker:9788392] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v42:[addLiteratureReference] [UpdateTracker:9788686] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v41:[add_removeInput] [UpdateTracker:9788180] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v43:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780719] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v62:[add_removeInput] [UpdateTracker:9788392] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v42:[addLiteratureReference] [UpdateTracker:9788686] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v41:[add_removeInput] [UpdateTracker:9788180] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v43:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
(precedingEvent)	[BlackBoxEvent:R-HSA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex

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