Reactome | Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

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Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:450295] ubiquitin-protein transferase activity of K63-linked polyUb TRAF6 complexes [endosome membrane]
category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId	450358
displayName	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
followingEvent	[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
input	[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
orthologousEvent	[BlackBoxEvent:R-GGA-573294] Activated TRAF6 synthesizes free K63 linked pUb chains - Gallus gallus [BlackBoxEvent:R-GGA-433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 - Gallus gallus [Polymerisation:R-DDI-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Dictyostelium discoideum [Polymerisation:R-DME-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Drosophila melanogaster [Polymerisation:R-GGA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Gallus gallus [Polymerisation:R-DRE-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Danio rerio [Polymerisation:R-SSC-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Sus scrofa [Polymerisation:R-BTA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Bos taurus [Polymerisation:R-CFA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Canis familiaris [Polymerisation:R-RNO-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Rattus norvegicus [Polymerisation:R-MMU-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Mus musculus
output	[Polymer:R-HSA-450152] K63polyUb [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Homo sapiens [BlackBoxEvent:R-HSA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Homo sapiens
releaseDate	2010-12-14
requiredInputComponent	[EntityWithAccessionedSequence:R-HSA-174100] UBE2E1 [cytosol] - Homo sapiens [Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532638] Gillespie, ME, 2010-03-02
schemaClass	Polymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-450358
summation	[Summation:450260] Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates f...
updateTrackers	[UpdateTracker:9790120] Update Tracker - [Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790120] Update Tracker - [Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - v35:[modifyText]
(precedingEvent)	[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
(hasEvent)	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation [Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex

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