Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Polymerisation
>
Entries
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
Show undefined attributes
Go to Details
authored
[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity
[CatalystActivity:450295] ubiquitin-protein transferase activity of K63-linked polyUb TRAF6 complexes [endosome membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
created
[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId
450358
displayName
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
edited
[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf
[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Homo sapiens
followingEvent
[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
input
[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
modified
[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
orthologousEvent
[BlackBoxEvent:R-GGA-573294] Activated TRAF6 synthesizes free K63 linked pUb chains. - Gallus gallus
[BlackBoxEvent:R-GGA-433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 - Gallus gallus
[Polymerisation:R-DME-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Drosophila melanogaster
[Polymerisation:R-GGA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Gallus gallus
[Polymerisation:R-SSC-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Sus scrofa
[Polymerisation:R-BTA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Bos taurus
[Polymerisation:R-CFA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Canis familiaris
[Polymerisation:R-RNO-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Rattus norvegicus
[Polymerisation:R-MMU-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Mus musculus
output
[Polymer:R-HSA-450152] K63polyUb [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Homo sapiens
[BlackBoxEvent:R-HSA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Homo sapiens
releaseDate
2010-12-14
requiredInputComponent
[EntityWithAccessionedSequence:R-HSA-174100] UBE2E1 [cytosol] - Homo sapiens
[Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol] - Homo sapiens
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:532638] Gillespie, ME, 2010-03-02
schemaClass
Polymerisation
species
[Species:48887] Homo sapiens
stId
R-HSA-450358
summation
[Summation:450260] Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates f...
Referrals
(hasEvent)
[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
(precedingEvent)
[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text