Reactome | Activation of TAK1 complex bound to activated TLR4 complex

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Activation of TAK1 complex bound to activated TLR4 complex Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity	[CatalystActivity:936943] protein serine/threonine kinase activity of activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
dbId	936951
displayName	Activation of TAK1 complex bound to activated TLR4 complex
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Homo sapiens
followingEvent	[Reaction:R-HSA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Homo sapiens [Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Homo sapiens [Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Homo sapiens [Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
input	[Complex:R-HSA-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] 4 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:450183] TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop [LiteratureReference:433972] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of TAK1 complex bound to activated TLR4 complex
orthologousEvent	[Reaction:R-GGA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Gallus gallus [Reaction:R-SSC-936951] Activation of TAK1 complex bound to activated TLR4 complex - Sus scrofa [Reaction:R-BTA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Bos taurus [Reaction:R-CFA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Canis familiaris [Reaction:R-RNO-936951] Activation of TAK1 complex bound to activated TLR4 complex - Rattus norvegicus [Reaction:R-MMU-936951] Activation of TAK1 complex bound to activated TLR4 complex - Mus musculus
output	[Complex:R-HSA-936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] 4 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-936951
summation	[Summation:450184] The TAK1 complex consists of Transforming growth factor-beta...
updateTrackers	[UpdateTracker:9788197] Update Tracker - [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex - v43:[modifyText] [UpdateTracker:9782070] Update Tracker - [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788197] Update Tracker - [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex - v43:[modifyText] [UpdateTracker:9782070] Update Tracker - [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex - v59:[modifyText]
(precedingEvent)	[Reaction:R-HSA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex [Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 [Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 [Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex
(hasEvent)	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex

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