Reactome | Auto ubiquitination of TRAF6 bound to the activated TLR4 complex

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Auto ubiquitination of TRAF6 bound to the activated TLR4 complex Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
dbId	936952
displayName	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
edited	[InstanceEdit:1018388] Shamovsky, V, 2010-11-16
eventOf	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Homo sapiens
followingEvent	[Reaction:R-HSA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Homo sapiens [Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Homo sapiens
input	[Complex:R-HSA-936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
orthologousEvent	[BlackBoxEvent:R-GGA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Gallus gallus [BlackBoxEvent:R-SSC-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Sus scrofa [BlackBoxEvent:R-BTA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Bos taurus [BlackBoxEvent:R-CFA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Canis familiaris [BlackBoxEvent:R-RNO-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Rattus norvegicus [BlackBoxEvent:R-MMU-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Mus musculus
output	[Complex:R-HSA-936965] K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Homo sapiens
releaseDate	2010-12-14
requiredInputComponent	[EntityWithAccessionedSequence:R-HSA-205753] UBE2V1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-206072] UBE2N [cytosol] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-936952
summation	[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
updateTrackers	[UpdateTracker:9789962] Update Tracker - [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - v36:[modifyText] [UpdateTracker:9788124] Update Tracker - [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789962] Update Tracker - [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - v36:[modifyText] [UpdateTracker:9788124] Update Tracker - [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
(precedingEvent)	[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Reaction:R-HSA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex